A recently published study (S. Sakata-2022) made in a japanese population, using a panel of next-generation sequencing (NGS), we examined > 300 adenocarcinomas of the lung, identified in approximately half of the cases, variants constants in the genes EGFR and KRAS, which provides useful information to study and identify variants in these genes in patients with lung adenocarcinomas.
Before deleterious mutations, the cell has an efficient repair system through the pathway Repair by Homologous Recombination (HRR), which allows you to repair mutations of the double-stranded, by activating a complex molecular mechanism that includes a team of genes, within which are found mainly BRCA1/2, ATM, PALB2, and RAD51; however, when there is a mutation in any of the genes of this pathway, is set to a Deficiency in the Homologous Recombination (HRD).
It has been estimated that the DNA suffers more than 10,000 variations on a daily basis as a result of errors in the replication, errors in the repair or absence of the same.
The chronic inflammation caused by bacterial and viral infections is strongly related to the etiology and the development of cancer, not only because of the inflammation caused by the infection, but by the integration of sequences of DNA and RNA in human cells.
The chronic inflammation caused by bacterial and viral infections is strongly related to the etiology and the development of cancer, not only because of the inflammation caused by the infection, but by the integration of sequences of DNA and RNA in human cells.
There are several Polyposis Colorectal Cancer Syndromes, in which familial adenomatous polyposis is the most classic, it is transmitted with an autosomal dominant character.
Have been classified into 2 types syndromes of colorectal cancer, depending on whether they are accompanying or not polyps.
To date, we have been able to identify most of the genes involved in different types of cancer. Thus, in breast cancer have been identified genetic variants in about 30 genes...
Por: Dr. Gildardo Fco. Zafra de la Rosa. Con el paso de los años y el avance de la tecnología los estudios genéticos se han hecho más específicos, en un inicio el cariotipo fue la mejor herramienta, mostraba todo el conjunto del material genético, pero su definición era muy baja, a principios de los 80`s...
Por: Dr. Gildardo Fco. Zafra de la Rosa. La NGS es una de las nuevas herramientas moleculares que han permitido analizar múltiples genes simultáneamente con un menor costo y tiempo. Es también llamada secuenciación masiva en paralelo, debido a que se basa en el ensamblado de secuencias de millones de bases a partir de fragmentos...
