Before deleterious mutations, the cell has an efficient repair system through the pathway Repair by Homologous Recombination (HRR), which allows you to repair mutations of the double-stranded, by activating a complex molecular mechanism that includes a team of genes, within which are found mainly BRCA1/2, ATM, PALB2, and RAD51; however, when there is a mutation in any of the genes of this pathway, is set to a Deficiency in the Homologous Recombination (HRD).
