{"id":20412,"date":"2026-03-25T00:48:58","date_gmt":"2026-03-25T00:48:58","guid":{"rendered":"https:\/\/cancercentertec100.com\/?p=20412"},"modified":"2026-03-25T00:52:04","modified_gmt":"2026-03-25T00:52:04","slug":"notigenetica-predisposicion","status":"publish","type":"post","link":"https:\/\/cancercentertec100.com\/en\/noti-genetica\/notigenetica-predisposicion\/","title":{"rendered":"NOTIGEN\u00c9TICA: PREDISPOSICI\u00d3N"},"content":{"rendered":"
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Por: Dr. Gildardo Zafra de la Rosa
Genetista de CCT100<\/span><\/span><\/em><\/span><\/span><\/figure>\n
La predisposici\u00f3n gen\u00e9tica a las enfermedades es un hecho bien determinado en la actualidad. Desde los antecedentes familiares registrados en la historia cl\u00ednica, es posible sospechar la presencia de ciertos rasgos que conducen a la enfermedad. En la era molecular actual, es posible fundamentar el riesgo de presentar una determinada condici\u00f3n patol\u00f3gica con bastante certeza, a trav\u00e9s de procedimientos de an\u00e1lisis del ADN, no solo las debidas a cambios f\u00edsicos en las bases nucleot\u00eddicas como las deleciones, duplicaciones o inversiones, sino tambi\u00e9n en las relacionadas con el efecto bioqu\u00edmico improntado por la metilaci\u00f3n, la fosforilaci\u00f3n y la acetilaci\u00f3n, principalmente, e inclusive con las modificaciones post-traduccionales que ocurren durante el proceso que transita de los genes a las prote\u00ednas.Estos efectos son relevantes especialmente en ciertas entidades cl\u00ednicas que representan un problema de salud general como es el caso de la diabetes.<\/p>\n

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Recientemente, se public\u00f3 un art\u00edculo que plantea que la poblaci\u00f3n mexicana tiene una de las mayores frecuencias mundiales, tanto de diabetes tipo 2, cuanto de la prediabetes. En este estudio se practic\u00f3 un an\u00e1lisis de ancestr\u00eda gen\u00f3mica, el cual identific\u00f3 ciertos genes de origen indigeno-americano involucrados en el metabolismo de la glucosa. Se observ\u00f3 que la presencia de estos genes afecta en mayor proporci\u00f3n a las mujeres en comparaci\u00f3n con los hombres y a los j\u00f3venes en comparaci\u00f3n con los adultos mayores.<\/p>\n

Ello indica que subyace la participaci\u00f3n de factores epigen\u00e9ticos relacionados con el g\u00e9nero, las hormonas, los h\u00e1bitos y los factores nutricionales que encuentran su efecto en la presentaci\u00f3n de la diabetes.<\/p>\n

Este estudio siembra un precedente que plantea interrogantes a despejar y con ellas se continuar\u00e1n observando con mayor precisi\u00f3n los mecanismos que condicionan la diabetes, con el objetivo de dise\u00f1ar estrategias de aplicaci\u00f3n cl\u00ednica, tendientes a prevenirla.<\/p>\n<\/figure>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"

La predisposici\u00f3n gen\u00e9tica a las enfermedades es un hecho bien determinado en la actualidad. Desde los antecedentes familiares registrados en la historia cl\u00ednica, es posible sospechar la presencia de ciertos rasgos que conducen a la enfermedad.<\/p>","protected":false},"author":1,"featured_media":20414,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[293],"tags":[346,438],"class_list":["post-20412","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noti-genetica","tag-adn","tag-predisposicion-genetica"],"yoast_head":"\nNOTIGEN\u00c9TICA: PREDISPOSICI\u00d3N<\/title>\n<meta name=\"description\" content=\"La predisposici\u00f3n gen\u00e9tica a las enfermedades es un hecho bien determinado en la actualidad. 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